Fat People Rolled Poor Genes, Concludes Largest-Ever Study

Body weight is “largely influenced” by genes, according to the largest-ever study of its kind. Researchers concluded that slim people won the genetic lottery, while obese people have the deck stacked against them from birth.
The study by Cambridge University aimed to determine why some people manage to stay thin with little effort, while others gain weight easily despite similar lifestyles.

Previous studies of twins have found that their differing body weight was largely influenced by their genes. It’s also been previously determined that genes can increase a person’s chance of being overweight, and in some people increases their chances of being obese from a young age.

Participants gave saliva samples to enable DNA analysis and answered questions about their general health and lifestyle, in what is thought to be the only study of its kind in the world.

The team then compared their findings with the DNA of 14,000 other volunteers, including 1,985 severly obese people and a further 10,433 people with a normal weight, and shared their results in a study published Thursday in the journal PLOS Genetics.

Results showed several common genetic variants that are already known to play a role in obesity. In addition, the team found new genetic regions linked to severe obesity and healthy thinness. To determine a person’s genetic risk score, researchers then added up the different genetic variants and found the results corresponded with their weight today.

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